For example, the 14 C-based birth-dating strategy suggested that the age-dependent decline in hippocampal neurogenesis is much less dramatic in humans as compared to rodents Spalding et al. Notably the role of NSCs during diseases is now being elucidated by several research groups around the world. Adult neurogenesis twenty years later: It also remains an intriguing possibility that adult NSCs may give rise to a diverse type of lineage-restricted progenitors and neuroblasts that are heterogeneous and regionally specified Figure 2A, B. However, recent in vivo clonal analysis has found only neuronal lineages from individual NSCs Calzolari et al.
Adult neural stem cells in the mammalian central nervous system.
Further evidence of a functional relationship between stem cells and vascular endothelial cells comes from the observation that endothelial cells release unidentified soluble factors that regulate proliferation of the stem cells and play an instructive role in neuronal fate specification Shen et al.
Anatomical perspectives on adult neural stem cells
Allison M. Stroke 39, — Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets.